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Gut Microbiota and Cancer: From Pathogenesis to Therapy

Gut Microbiota and Cancer: From Pathogenesis to Therapy

Posted by ACH2015 on Aug 14, 2019 5:24 am

From NCBI (National Center for Biotechnology Information) Journals - Jan. 11th, 2019.

Cancer treatments can and do cause imbalance in our gut health. Collateral damage that can't be avoided. Many systemic drug or radio logic treatments create this imbalance.

This site details many of us discussing the specifics about whether or not to take vitamins, supplements, reduce or increase our intake of natural or supplemented antioxidant in relation to treatments, and of equal importance rebuilding our specific gut health. Quite simply, what's good for me may not be good for you, so invest some time and effort into researching your specific needs. Pay attention to your specialists recommendations about maintaining or modifying your own daily nutritional habits and understand the importance of looking at your individual needs.

I have paid great attention to the fallout and collateral damage done (to me) as a result of my own cancer treatments. It was time to reexamine my gut health. One doctor gave me an R/X for strong antacids, but I came to realize it was in my best interests to look at solving the problem vs. treating the symptom. So I am in the midst of doing so.  Gut health is an important factor in our lives, and there is no one size fits all as to the do's and don'ts of maintaining or restoring your individual gut health before, during and after cancer treatments.

Personally, I read these articles in their entirety, but if you don't - I've highlighted the conclusions below, that wrap up and make sense of all this information.

From the article:

Conclusions and Future Perspectives

The relationship between gut resident microbiota and their host is complex. Each individual inherited a specific gut microbiota footprint since their birth, and their intestinal microbiota develops and changes with aging, diet and lifetime exposure to the heterogeneous environment. Indeed, this balance is very delicate and subjected to multiple changes during the entire lifespan.

Nowadays, there is a growing attention towards the characterization of the gastro-intestinal microbiota composition and functionalities. Genetics, together with functional studies, highlighted a dual role played by the gut microbiome in cancer. Some bacterial subpopulations are able to rise during gut dysbiosis and, in turn, to trigger the formation of an inflammatory and pro-cancerogenic environment. On the other hand, many gut derived probiotics are able to protect the host, re-establishing the conditions of a healthy intestinal microbiota within dysbiotic patients, including cancer patients.

LGG is a very good example of a probiotic well studied in cancer, often administered as complementary therapeutic to cure dysbiosis. Given the observed functions as anti-inflammatory and anti-cancer agent in both cellular and animal models, this probiotic may be suggested to be further characterized as adjuvant in integrated anti-cancer therapies in the future.

In line with that observation, this year have witnessed novel breakthrough studies on the association between probiotics and anti-cancer therapy efficacy, as three parallel studies identified specific gut species populating the gastro-intestinal tract of cancer immunotherapy responders, able to improve the efficacy of immunotherapy treatments.

That questions the usage of both probiotics and FMT in cancer therapy, either as tools to repopulate cancer patients’ damaged intestine or even as proper adjuvants in immunotherapy and other kinds of anti-cancer therapies. Correspondingly, care needs to be pursued as patients are often immunocompromised, therefore it is important to evaluate the specific side effects of administering selected bacterial species to such sensitive individuals. In the future, the design of novel experimental trials may undertake a personalized-integrated approach, considering the specific clinical and pathological background of each single patient to be treated, in order to gain only the positive outcomes of probiotics administration and/or fecal transplants, possibly without any harmful side effect.

Read the article:

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=4&cad=rja&uact=8&ved=2ahUKEwja7M-89IHkAhVxds0KHds7D4QQFjADegQICBAB&url=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6356461%2F&usg=AOvVaw0cAXUlBkq2-YTx5roYVHEB

I repeat, just because a product is legal to sell doesn't mean it safe, healthy or the right choice for you. Many of us don't (and can't) read the microscopic warnings on products,or read studies but it really is worth the effort.

So, its more investigation for me, more 1 on 1 with the medical team to seek out the best management solution for repair and moving forward.

Not a simple process, but very worthwhile. Your cancer treatment plan is individualized, so too should be your life's rebuilding plan.

ACH2015



 

Re: Gut Microbiota and Cancer: From Pathogenesis to Therapy

Posted by Runner Girl on Aug 14, 2019 9:43 am

Thanks for this ACH2015‍ ,

Given my history of gut related issues I am always interested in new studies and information.  

Runner Girl - Gayle

Re: Gut Microbiota and Cancer: From Pathogenesis to Therapy

Posted by Lacey_adminCCS on Aug 14, 2019 12:01 pm

ACH2015‍ 

I thought this might interest you from out Research Horizon's section of our website: Gut bacteria may influence how well Immunotherapy works

Re: Gut Microbiota and Cancer: From Pathogenesis to Therapy

Posted by ACH2015 on Aug 14, 2019 12:54 pm

Thank you sharing the link Lacey_adminCCS‍ .

That is a very important part of the complex process between gut health and immuno and other cancer treatments.

I will be contacting the CCS directly to seek some specific cancer / gut health references in relation to my specific treatments and current status.

ACH2015

Re: Gut Microbiota and Cancer: From Pathogenesis to Therapy

Posted by Runner Girl on Aug 16, 2019 2:21 pm

Further on this topic, I came across this article on CTV News. 

Why fecal transplants could be the next frontier in fighting skin cancer

https://www.ctvnews.ca/health/why-fecal-transplants-could-be-the-next-frontier-in-fighting-skin-cancer-1.4552783

It's all about the microbiota!

They are also looking for volunteers to provide clean stool samples.

Runner Girl

Re: Gut Microbiota and Cancer: From Pathogenesis to Therapy

Posted by Lacey_adminCCS on Aug 16, 2019 2:38 pm

Runner Girl‍ 

Oh Wow!