The last few years have seen millions of people sending saliva samples to private companies for DNA analysis to better understand their risks of developing disease. Yet such direct-to-consumer (DTC) genetic tests are limited in scope, and typically only interrogate for a few well-studied disease-causing variants.
A new study estimated how likely such tests are to miss pathogenic variants and found that if only DTC testing were undertaken, an overwhelming majority of people would receive clinical “false-negative results” for mutations associated with breast, ovarian, and colorectal cancer.
Results varied across ethnic groups; in some, the chance of missing a disease-causing variant could be as high as 100%.
Read the article:
Popular Genetic Tests Miss Many Cancer-Associated Genetic Variants
Good information for anyone seeking alternative means to genetic testing for yourself or family members. There was discussion a short time ago in another thread that mentioned the shortfalls of Direct to Client DNA testing. Definitely worth repeating here.
You get what you pay for. I'll take (and pay for if need be) the test at the lab recommended by my specialist any day.